General Information

  • ID:  hor001549
  • Uniprot ID:  Q9DGD4
  • Protein name:  Gonadotropin inhibitory hormone-related peptide 2
  • Gene name:  GNIH
  • Organism:  Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  Specifically expressed in the diencephalon.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Coturnix (genus), Perdicinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SSIQSLLNLSQRF
  • Length:  13(142-154)
  • Propeptide:  MEIISTQKFILLTLATVAFLTPHGACLDELMKSSLESREDDDDKYYETKDSILEEKQRSLNFEEMKDWGSKNFMKVNTPTVNKVPNSVANLPLRFGRSNPEERSIKPSAYLPLRFGRAFGESLSRRAPNLSNRSGRSPLARSSIQSLLNLSQRFGKSVPISLSQGVQESEPGM
  • Signal peptide:  MEIISTQKFILLTLATVAFLTPHGAC
  • Modification:  T13 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hypothalamic factor, responsible for the negative regulation of gonadotropin secretion.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P09916-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-P09916-F1.pdbhor001549_AF2.pdbhor001549_ESM.pdb

Physical Information

Mass: 170691 Formula: C65H109N19O21
Absent amino acids: ACDEGHKMPTVWY Common amino acids: S
pI: 10.55 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 5
Hydrophobicity: 3.85 Boman Index: -2358
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 120
Instability Index: 7266.15 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  NA